趙治宇教授.台大分子醫學影像中心.美國紐約大學生物物理博士 .阿茲海默症IAE全球產官學研計畫主持人

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日期:2021/09/15   IAE

趙治宇教授. 台大分子醫學影像中心暨應用物理研究所

美國紐約州立大學生物物理博士

國際學士院阿茲海默症全球產官學研中心計畫主持人

台大分子醫學影像中心-蛋白質電子斷層部主任
 

液態生物電子顯微鏡發明人
 

受邀瑞典皇家科學院提名2013年諾貝爾物理獎
 

受邀瑞典皇家科學院提名2014年諾貝爾物理獎
 

中華民國物理學會最佳論文獎
 

台北市優秀傑出青年獎第一名
 

國立台灣大學傅斯年研究獎
 

中華民國奈米核心設施計畫主持人
 

Mark Diamond Research Fund Fellow, State University of New York, USA.

趙治宇博士於1992年從台大物理系畢業,並於1997年在美國紐約州立大學取得生物物理博士的學歷,目前在台大分子醫學影像中心以及台大應用物理研究所擔任教授,並為台大分子醫學影像中心-蛋白質電子斷層部的負責人。

趙治宇教授主要著重於生物醫學以及生醫物理技術的開發,生醫技術的發展可用於解決神經、幹細胞與癌症研究上相關之生物醫學問題,目前趙治宇教授主要的研究方向在使用物理/能量的方法進行活化腦神經細胞,使退化的神經元得以被修復,因為目前阿茲海默症的治療藥物受限於腦血屏障均很難達到有效的治療,因此開發以物理方法為基礎的電刺激、光刺激和熱刺激的治療方式,相信未來可能會是治療阿茲海默症的主流方法,進而期待能解決當今國際上因老年化所產生的諸多問題,相信對各個國家的醫療、公衛和社會都會有莫大的幫助和影響。

再者,趙治宇教授為國際知名的生物電子顯微鏡專家,趙教授領先世界其他團隊於2004年突破性地使用電子顯微鏡首次能夠觀察到fully-hydrated含水生物膜的結構,此項結果發表在國際頂尖期刊並同時登上科學人雜誌的報導,並已取得30件以上世界各國的專利,趙教授他發明的「液態電子顯微技術」目前已廣泛的應用在相關科技領域,使得研究人員能夠在液態環境下觀察奈米級生物分子的結構或形貌的變化,所以這項技術的發明對許多科技領域的研發可說是一大貢獻。此外,趙教授成功解出「高攜氧量血紅蛋白之近原子級動態結構」,傑出成果發表在Nature雜誌網路版的Scientific Reports,趙教授團隊目前正針對人體局部缺氧急性重症患者進行急救藥物之開發,可望對缺氧型急性重症之醫療帶來新的曙光。

 

Dr. Chih-Yu Chao graduated from the Department of Physics, National Taiwan University (NTU) in 1992, and obtained a PhD degree in Biophysics from the State University of New York at Buffalo in1997. He is currently a Professor at the Molecular Imaging Center and Institute of Applied Physics inNTU. He also serves as a director for Cryo-electron microscopy department in Molecular Imaging Center, NTU.

Professor Chih-Yu Chao mainly focuses on the biomedical research and the development of bioengineering technology. His study can be applied to solve biomedical problems related to the research of nerves, stem cells, and cancers. Currently, Prof. Chao’s major research interest is the use of physics/energy methods to activate the degenerated neuron cells. To date, the conventional treatment of Alzheimer’s disease (AD) is limited by blood brain barrier, so that it is difficult to achieve effective treatment on AD. Therefore, it is anticipated that the physical methods such as electrical, light energy, and thermal stimulations may be the mainstream treatment for AD in the future. Prof. Chao looks forward to solving the problems caused by aging via such novel AD treatment, and believes that it will have great help and influence on the medical, public health, and society of various countries in the world.

In addition, Prof. Chao is an internationally renowned expert in biological electron microscopy (Bio-EM). He led other teams in the world to use electron microscope to observe the structure of fully-hydrated biological films for the first time in 2004. His invented Bio-EM technique has been awarded more than 30 international patents. Nowadays, the Bio-EM technique has been widely used in the related fields of science and technology, allowing researchers to observe changes in the structure of biomolecules in a liquid environment in EM. Therefore, the invention of this technique is a great contribution to the research and development of many scientific and technological fields. Furthermore, Prof. Chao recently resolved the “Near-atomic dynamic structure of a highly oxygen-carrying hemoglobin”, and this outstanding result was published in the Scientific Reports of Nature magazine. Currently, his research team is developing emergency medicines for hypoxic acute severe patients,which is expected to bring new light to the medical treatment of hypoxic acute severe illness.

Effect of high-frequency low-intensity pulsed electric field on protecting SH-SY5Y cells against hydrogen peroxide and β-amyloidinduced cell injury via ERK pathway